Vascularization and its Role in Medicine and Tissue Engineering

This book provides comprehensive information to all medical doctors regarding novel angiogenic and bioengineering medical treatments. Tissue healing is significantly hampered by ineffective neovascularization at the site of the defect, resulting in poor clinical outcomes. The fabrication of biomaterial-based scaffolds with adequate vascularizing abilities is the prevailing challenge that has drawn considerable attention from the scientific community. The decisive roles of vascularized biomaterials as bone and skin substitutes, and in various soft and hard tissue engineering, have been investigated widely. Cell-based and scaffold encapsulating bioactive molecules-based approaches are essential means of developing efficient angiogenesis in tissue defects. To fulfill the necessity of an optimum long-term vascularizing scaffold, it should essentially be economic, controlled, and reproducible. While a lot has been achieved towards acknowledging newer molecules with vascularizing abilities; there is a broad gap wherein we need to develop in vitro vascularized implants as well as tissues and organs with the advanced technologies and knowledge at our disposal.