This comprehensive book provides healthcare professionals with essential knowledge and practical strategies for managing critically ill COVID-19 patients. Covering pathophysiology, clinical presentation, advanced respiratory support, pharmacological interventions, hemodynamic stabilization, renal replacement therapy, and nutritional support, the book integrates evidence-based practices with lessons learned from frontline experiences. Designed for physicians, intensivists, nurses, and allied health professionals, this volume emphasizes a multidisciplinary approach to improve patient outcomes, reduce mortality, and enhance healthcare preparedness. It also reflects on resilience, adaptation, and readiness for future infectious disease challenges. Whether as a reference, educational tool, or practical guide, this book is an invaluable resource for those confronting the ongoing global pandemic and preparing for future critical care challenges.