Acute tubulointerstitial nephritis and uveitis syndrome (TINU)

Tubular and interstitial nephropathy with uveitis (NITU ) syndrome is a rare oculo-renal disorder. We will describe the clinical and biological aspects of this entity. Our study was retrospective from 1996 to 2024. All patients had histologically proven interstitial renal involvement and ocular involvement. Six patients were included, including 5 women and 1 man with an average age of 39. Ocular involvement was inaugural in 4 cases and concomitant with renal involvement in 2. Ophthalmological examination revealed anterior and intermediate uveitis in 3 cases each. Biological inflammatory syndrome and renal failure were constant. Urinalysis revealed mild proteinuria with aseptic leukocyturia in 4 cases each; microscopic hematuria in 2 cases and glycosuria without diabetes. Corticosteroids (1mg/Kg/day) were prescribed with boluses of methylprednisolone, mydriatic eye drops and cortcoide eye drop for uveitis. General corticosteroid therapy was discontinued in 5 cases and maintained in 1.