Ras and Cancer in the 21st Century

Ras proteins are critical molecular switches in signaling mechanisms that control cell behavior and are frequently mutated in cancer. This volume examines the functions of Ras, how its activation leads to tumorigenesis, and ways in which excessive Ras signaling may be targeted therapeutically.

Topics covered in this essential volume include:
- KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer
- P13K: A Crucial Piece in the RAS Signaling Puzzle
- Targeting Ras with Macromolecules
- Post-Translational Modifications of RAS Proteins
- Targeting the MAPK Pathway in RAS Mutant Cancers
- Ras-Mediated Activation of the Raf Family Kinases