Handbooks in Pharmacology and Toxicology

Recent research in cell death mechanisms has rekindled interest in PARP''s (Poly (ADP-Ribose) Polymerase) intriguing role in necrosis and apoptosis. While the details of how PARP1 functions are still being elucidated, it has tremendous potential as a promising drug target. PARP inhibitors'' dual actions of preventing cell death and abating inflammati