Hematopoietic Stem Cell Transplantation for Neurologic Diseases

Intense immunosuppression followed by Hematopoietic Stem Cell Transplantation for Neurological Diseases (HSCT) has been evaluated as a possible therapeutic tool in severe autoimmune diseases for the last 20 years. In the neurological field, HSCT has been widely investigated for the treatment of multiple sclerosis and evidence is accumulating about its potential use in neuromyelitis optica, stiff person syndrome, myasthenia gravis and many immune neuropathies. This volume summarizes that research. Besides their strong clinical relevance, studies on HSCT in neurological diseases have contributed to mew insights on the pathological mechanisms underlying CNS autoimmunity. - Reviews immunological mechanisms of HSCT and CNS autoimmunity- Identifies neurological diseases showing treatment efficacy with HSCT- Includes MS, myasthenia gravis, neuromyelitis optica, and more- Covers early and late side effects of HSCT