Halogenation of Organic Compounds Using New Reagent Systems

As an effort to remove the use of venomous and expensive organic solvents used in conventional bromination methods, Cetylpyridinium Tribromide (CetPyTB) has been synthesized from a different route and its reactivity premeditated. Its easy method of preparation, mildness and effectiveness in organic reactions such as brominations shows that the Cetylpyridinium Tribromide as a reagent could be a valuable addition to the obtainable lot of reagents. In conclusion, we have established a practical method using N- Chlorosuccinimide (NCS) as a substitute to sodium periodate, sodium perborate and hydrogen peroxide (H2O2) in the oxidative chlorination of arenes and other aromaics using HCl in aqueous medium. The advantage of this system involves no use of organic solvent, mild reaction conditions and upright yield of chlorinated product. It provides a fast, noteworthy and simple system for bromination for the viable and particular union of pharmaceutically-critical brominated intermediated utilizing aq. AlBr3-Br2 system as a brief brominating specialists under aqueous conditions.