Biological compartments and Molecular Communication in Lung Diseases

This book presents an integrative and systems-level perspective on lung biology by emphasizing the role of cellular, subcellular, and molecular compartments in maintaining pulmonary homeostasis and driving disease progression. The lung is portrayed as a highly organized and dynamic organ in which efficient communication among epithelial cells, immune populations, stromal cells, and vascular components is essential for gas exchange, host defense, and tissue repair. Rather than viewing lung function and pathology as outcomes of isolated molecular events, the book frames pulmonary health and disease as emergent properties of coordinated biological communication networks.The early chapters introduce the concept of biological compartmentalization in the lung, highlighting how anatomical regions, organelles, and extracellular vesicles function as regulated units of information exchange. Core principles of signal transduction and receptor-mediated communication are discussed to explain how cells sense environmental cues and translate them into appropriate biological responses.