Angiogenesis in Brain Tumors

The mutual relationship between tumor growth and concomitant neovascularization offers important insight into the biology of brain tumors and the development of new treatment strategies. Many of the early findings in the biology of angiogenesis have been investigated using brain tumor models. Angiogenesis in Brain Tumors is part of the "Cancer Treatment and Research" book series and this volume provides an overview of the biology of angiogenesis in the central nervous system, the role of angiogenesis in brain tumor development and growth, and therapeutic applications including clinical trials. 'Angiogenesis is a critical component of tumor growth. This text evaluates the role of neovascularization in brain tumor development and growth, and presents therapeutic applications including clinical trials. Distinguished investigators in the field discuss the critical signaling cascades that affect angiogenesis and evaluate strategies that inhibit the process that may provide therapeutic benefit against these devastating cancers.' Steven T. Rosen, M.D., Series Editor