This book constitutes the proceedings of the International Joint Conference on Rules and Reasoning, RuleML+RR 2022, held in Berlin, Germany, during September 26-28, 2022. This is the 6th conference of a new series, joining the efforts of two existing conference series, namely "e;RuleML"e; (International Web Rule Symposium) and "e;RR"e; (Web Reasoning and Rule Systems).The 18 full research papers presented in this book were carefully reviewed and selected from 54 submissions. The papers cover the following topics: answer set programming; foundations of nonmonotonic reasoning; datalog; queries over ontologies; proofs, error-tolerance, and rules; as well as agents and argumentation.