This book brings together the debate concerning personal identity (in metaphysics) and central topics in biomedical ethics (conception of birth and death; autonomy, living wills and paternalism). Based on a metaphysical account of personal identity in the sense of persistence and conditions for human beings, conceptions for beginning of life, and death are developed. Based on a biographical account of personality, normative questions concerning autonomy, euthanasia, living wills and medical paternalism are dealt with. By these means the book shows that "e;personal identity"e; has different meanings which have to be distinguished so that human persistence and personality can be used to deal with central questions in biomedical ethics.