This volume explores the emerging understanding that severe burns may act as catalysts for neurodegenerative processes, resulting in long term sensorimotor, cognitive, and functional decline. Burn induced systemic inflammation, neuroinflammatory cascades, and ICU related neurological syndromes collectively form a clinical continuum that mimics or contributes to neurodegeneration. Framed within this paradigm, this book offers an evidence based approach to neuromotor rehabilitation that addresses both central and peripheral nervous system complications. It bridges acute trauma with chronic neurofunctional loss, positioning physical therapy as a pivotal intervention to modulate degeneration, support neuroplasticity, and enhance recovery.