Translational Research Methods for Neuropathic Pain

This volume provides a comprehensive overview of experimental models of neuropathic pain and state-of-the-art strategies for the assessment of pain and its associated behavioral and functional outcomes. The book is organized into two complementary parts. Part One focuses on experimental models that, despite their diverse etiologies, converge on a shared neuropathic substrate, ranging from the spared nerve injury (SNI) and FRICT-ION (Foramen Rotundum Inflammatory Constriction Trigeminal InfraOrbital Nerve) models to central traumatic neuropathies and systemic conditions such as diabetic and toxin-induced neuropathies. Part Two is dedicated to pain-related manifestations, with particular emphasis on endophenotypic outcomes, ultrasonic vocalizations, burrowing behavior, anxiety- and depressive-like phenotypes and executive function. In keeping with the tradition of the Neuromethods series, chapters include the kind of detail and key advice from the specialists needed to get successful results in the researchers’ laboratories. Thorough and practical, Translational Research Methods for Neuropathic Pain is a valuable resource for all researchers looking to learn more about this important and developing field.