The two-volume set LNICST 587 + 588 constitutes the refereed proceedings of the EAI 15th International Conference on nternational Conference on e-Infrastructure and e-Services for Developing Countries, AFRICOMM 2023, which took place in Bobo-Dioulasso, Burkina Faso, in November 2023.The 59 full papers presented in these two volumes were carefully reviewed and selected from 72 submissions.The papers are organized in the following topical sections:Part I: Digital economy, Digital transformation, e-Government and e-services; ICT infrastructures for critical environmental conditions; Wireless networks; E-health; Cybersecurity and Privacy.Part II: Systems and cloud computing; Artificial Intelligence; Ontology and data preparation; Responsible Artificial Intelligence for Sustainable Development in Africa (workshop).