The effect of Moringa oleifera on oxidative stress of Brain Damage

A short-term oral toxicity study of 14- day was evaluated in mice to verify the safety of M.oleifera leaves extract. Oral dose performed in different concentrations the extract by three doses daily. Results the tests of the acute toxicity study have shown non-toxic at these concentrations. The present study is involved also the investigation of the antioxidant capacity of M. oleifera leaves extract prepared with different concentrations in vitro using by (DPPH & ORAQ) method. Extract has shown inhibition of free radicals effects, the M. oleifera leaves extract has given good results compared to standard antioxidant (Vitamin C).In this study, have proved that M.oleifera leaves extract, it possesses the ability to protect the brain from effects of oxidative stress caused by experimentally induced hypoxia in male rats through its ameliorative effect on the oxidative stress in the treatment group (C). In the present study, it was noticed that M.oleifera could greatly enhance the activity of antioxidant enzymes (SOD, GSH-Px and GSH), and decreased the oxidative stress markers (MDA and ROS) . M. oleifera leaves extract seems to balance the endogenous antioxidant activity .