Solute Carrier Protein Family

Selective transport mechanisms across the cell membrane are essential for maintaining cellular integrity and physiological balance. Drug transport proteins (DCPs) mediate the movement of endogenous molecules and therapeutic agents into and out of cells. These proteins are highly expressed in the liver, kidneys, brain, and intestines, where they regulate key cellular functions. Substances such as sugars, amino acids, vitamins, neurotransmitters, and xenobiotics are transported through these mechanisms, preserving physiological balance and protecting cells from harmful compounds. The solute carrier (SLC) protein family directly influences drug absorption, distribution, metabolism, and excretion, thereby affecting therapeutic efficacy, toxicity, and drug-drug interactions. Transporter expression and activity are modulated by genetic, physiological, and environmental factors. Recent molecular and pharmacogenetic studies show that SLC transporters contribute to disease pathophysiology and represent promising therapeutic targets, highlighting the importance of research and clinical practice.We hope this book will serve as a valuable guide for researchers.