Oral Bioavailability Assessment

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. •    Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability •    Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development •    Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development •    Includes chapters about pharmacokinetic  modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) •    Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development