Human papillomavirus and its relationship to cervical cancer

In Mexico, cervical cancer (CaCu) is the second leading cause of cancer death in women. In developing countries such as ours, most cases of CaCu are diagnosed in advanced stages of the disease, which leads to high mortality and high costs in the management of patients, as well as serious implications for the quality of life of patients and their families. Within the natural history of the CaCu disease it has been described that it is preceded by pre-invasive lesions, so this has allowed to describe the cytological and histological abnormalities recognized and has generated to consider the presentation of the clinical stage to the pre-clinical stage. From the pathology point of view, any intraepithelial lesion can evolve into a carcinoma, which highlights the importance of early diagnosis in order to reduce morbidity and mortality rates due to this neoplasm.