High Performance Computing

This book constitutes the proceedings of the 12th Latin American Conference on High Performance Computing, CARLA 2025, held in Kingston, Jamaica, during September 22–26, 2025. The 16 full papers included in this book were carefully reviewed and selected from 28 submissions. They were organized in topical sections as follows: High-Performance Computing (HPC); Artificial Intelligence at HPC Scale; and High-Performance Computing Applications.