Chemical Engineering in the Pharmaceutical Industry

This book deals with the elements of chemical engineering science unique to drug development, and commercialization specifically related to the successful manufacture of Active Pharmaceutical Ingredient. It emphasizes the need for scientific integration of Chemical Engineering and Synthetic Organic Chemistry during R&D, as well as with manufacturing Engineers, Analytical Chemists and other scientific disciplines necessary to deliver pharmaceuticals to the market place. This book covers the basic chemical engineering theories with its emphasis toward providing experimental methods, analysis, and contemporary process modeling methods in chemical engineering. It provide guidance on analytical methods for Engineers in R&D as well as manufacturing. In addition, emphasis is given on experimental techniques and considerations necessary to address scale-up issues and approach general process design related challenges to pharmaceutical process R&D. As a professional reference it is intended to be part “text” book and part “How To” book, and includes many worked examples related to problem solving via experimental and modeling methods. The new edition of the Active Pharmaceutical Ingredients volume includes new chapters on vent-sizing for emergency relief systems, reaction calorimetry, kinetic modeling. Additionally most of the chapters are updated or expanded with additional example calculations and case studies.