Are There Age, Urban-Rural, Gender, and Sex-Based Differences in Autoimmune and Autoinflammatory Diseases ?

Autoimmune and autoinflammatory diseases are a large heterogeneous group of diseases that share in common the chronic inflammatory process, but their clinical and biological expressions are extremely variable. These chronic inflammatory diseases sharing similar immuno-genetic and pathophysiological characteristics are grouped into either autoimmune diseases' nosological entity or autoinflammatory diseases'nosological entity. Consequently, similar therapeutic targets, diagnostic and therapeutic tools, diagnostic and therapeutic strategies, and preventive medicine strategies for these nosological entities and sub-nosological entities could be developed. Although research works have investigated the relationship between the age group, urban-rural, gender and sex-based differences and certain autoimmune and autoinflammatory diseases taken individually. However, there are no studies that have explored globally and exhaustively this relationship between the age group, urban-rural, gender and sex and the autoimmune and autoinflammatory diseases.