This book constitutes the refereed proceedings of the 13th International Conference on Optimization and Applications, OPTIMA 2022, held in Petrovac, Montenegro, during September 26-30, 2022.The 17 full papers and presented were carefully reviewed and selected from 43 submissions. They were organized into the following as follows: mathematical programming; global optimization; discrete and combinatorial optimization; optimal control; optimization and data analysis; and game theory and mathematical economics.