Introduction to Group Sequential Methods with Applications to Survival Data

In sequential analysis, the sample size is not fixed in advance. Instead, data are evaluated as they are collected, and further sampling is stopped in accordance with a pre-defined stopping rule as soon as significant results are observed. Although there are already good texts on the relevant theory and methodology of sequential analysis, this book is unique in its examples and R and SAS programs. Medical statisticians involved in planning and conducting clinical trials will find this book very useful.