Agenesis of corpus callosum with colpocephaly

Non-syndromic agenesis of the corpus callosum is a rare congenital disorder that has not been described or documented in Iraq. In this book, two Iraqi infants with non-syndromic agenesis of the corpus callosum are described. One infant had the isolated type and the second infant had agenesis of the corpus callosum associated with colpocephaly. Both infants had the clinical features of the syndrome resulting from the associated failure of neuronal migration including hypotonia with poor spontaneous movements, and poor head control, and no response to voice. The infant with corpus callosum associated with colpocephaly was treated with a novel therapeutic approach aiming at improving brain functions and accelerating development. She received two medications given by intramuscular injections in five successive therapeutic courses over three months period. Treatment was associated with significant improvement. The second patient didn't receive any specific therapy during three months of observation and he didn't show any obvious improvement despite he didn't have colpocephaly.