This book constitutes the refereed proceedings of the 10th International Conference on System Analysis and Modeling, SAM 2018, held in Copenhagen Denmark, in October 2018. The 12 full papers and 2 short papers presented were carefully reviewed and selected from 24 submissions. The papers describe innovations, trends, and experiences in modeling and analysis of complex systems using ITU-T's Specification and Description Language (SDL-2010) and Message Sequence Chart (MSC) notations, as well as related system design languages - including UML, ASN.1, TTCN, SysML and the User Requirements Notation (URN). This year's edition of SAM will be under the theme "e;Languages, Methods, and Tools for Systems Engineering"e;, including languages and methods standardized by the ITU-T, and domain-specific languages. Also included are software engineering technologies, such as for requirements engineering, software verification and validation, and automated code generation.