Nonlinear Models for Medical Statistics

This text provides an introduction to the use of nonlinear models in medical statistics, It is a practical text rather than a theoretical one and assumes a basic knowledge in statistical modelling and of generalized linear models. The book first provides a general introduction to nonlinear models, comparing them to generalized linear models. It describes data handling and formula definition and summarises the principal types of nonlinear regression formulae. there is an emphasis on techniques for non-normal data. Following chapters provide detailed examples of applications in various areas of medicine, epidemiology, clinical trials, quality of life, pharmokinetics, pharmacodynamics, assays and formulations, and molecular genetics. The book concludes with appendicies describing data handling and model formulae in more detail, and given ways of modelling dependencies in repeated measurements, and data for the exercises.