This book presents an advanced interdisciplinary framework combining artificial intelligence, molecular imaging, and nanotechnology to investigate the role of microRNAs in Alzheimer's disease. The book explores how AI-driven analysis enhances the design and interpretation of PET-based nanoprobes for precise detection, tracking, and quantification of microRNA activity in the brain. Emphasis is placed on diagnostic innovation, early disease detection, and mechanistic insights into neurodegeneration. By integrating computational modeling, biomedical imaging, and molecular neuroscience, the book demonstrates how intelligent nanoprobes can uncover hidden regulatory pathways and biomarkers associated with Alzheimer's progression. Designed for researchers, clinicians, and graduate students, this work highlights the transformative potential of AI-powered PET nanoprobes in precision medicine, neuroimaging, and future therapeutic strategies for neurodegenerative disorders.