Microwave Fixation of Labile Metabolites

Microwave Fixation of Labile Metabolites documents the proceedings of an official Satellite Symposium of the 8th International Congress of Pharmacology held in Tokyo, Japan, on 25 July 1981. The Symposium was entitled "e;"e;Drug Effects on Rapidly Metabolized Compounds in the CNS: Rapid Tissue Fixation with Microwave Irradiation."e;"e; The volume begins with a discussion of the use of microwave irradiation to study the concentration and interrelationships of neurochemicals in the brain. This is followed by papers on the effects of immobilization on the increases in cerebellar cyclic GMP induced by cold exposure or apomorphine; importance of rapid enzymatic inactivation prior to the determination of endogenous levels of catecholamines; use of glycolic acid to study catecholamines in the brain following microwave irradiation. Also include are studies on methods for preventing the post mortem increase in y-aminobutyric acid (GABA); the effect of microwave irradiation on catecholamine levels in the central nervous system; and effect of microwave irradiation in the brain histamine level of rats.