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HIV Interactions with Host Cell Proteins
The study of viruses necessarily involves dissecting the intimate details of cellular pathways. Viruses have often been employed as tools in studying cellular pathways, as was done …
Cholera Outbreaks
The most feared attribute of the human pathogen Vibrio cholerae is its ability to cause outbreaks that spread like wildfire, completely overwhelming public health systems and …
Signalling from Internalised Growth Factor Receptors
Mammalian cells are to a large extent controlled by the environment. Dif- fusible factors (growth factors, cytokines, and hormones) released by oth- er cells in the body bind to …
Chemokines and Viral Infection
Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) …
Kaposi Sarcoma Herpesvirus: New Perspectives
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Nuclear pre-mRNA Processing in Plants
In recent years nuclear pre-mRNA processing has taken center stage as an important regulator of gene expression and ultimately growth and development. Large-scale genome and cDNA …
Leptospira and Leptospirosis
This volume covers all aspects of infection by pathogenic Leptospira species, the causative agents of the world’s most widespread zoonosis. Topics include aspects of human and …
Cell Entry by Non-Enveloped Viruses
The means by which non-enveloped viruses penetrate cellular membranes during cell entry remain poorly defined. Recent findings indicate several members of this group share a common …
Swine Influenza
From the first detailed clinical description of the disease in the Midwestern United States in 1918, to the isolation of the causative agent, the first of any influenza virus, in …
Interferon: The 50th Anniversary
Over the last half of century interferon (IFN), originally discovered as an antiviral protein, has developed from an inhibitor of viral replication to a major force in the …
Molecular Mechanisms of Bacterial Infection via the Gut
Our gut is colonized by numerous bacteria throughout our life, and the gut epithelium is constantly exposed to foreign microbes and dietary antigens. Thus, the gut epithelium acts …
Protein Complexes that Modify Chromatin
An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels …