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totalt 14 träffar
Acute Promyelitic Leukemia
Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal …
Bacterial Infection: Close Encounters at the Host Pathogen Interface
When it comes to bacterial disease, we are living in a state of false security. Antibiotics have indeed brought unprecedented health benefits, protection from and cure of bacterial …
Retroviral Insertion and Oncogene Activation
An integrated retrovirus effectively becomes part of the cellular genome, but with the difference that the virus to a large extent retains control over its own expression through …
Cyclin Dependent Kinase (CDK) Inhibitors
More than 10 years ago, the discovery of cyclin-dependent ki nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control. Not only were both of …
Phosphoinositide 3-kinase in Health and Disease
PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K …
Oncogenes and Retroviruses
The newest volume in the Current Topics in Microbiology and Immunology series edited by Dr. Vogt and dealing with oncogenes and retroviruses contains four review articles by …
RNA Interference
In the last few years the major effect that RNAi has had in invertebrate systems like C.elegans and drosophila is beginning to take hold in mammalian systems through both single …
Praxis der Plastischen Chirurgie
In Anlehnung an die „Chirurgische Therapie" (Prof. Rudolf Pichlmayr) hat Prof. Dr. med. Peter Vogt gemeinsam mit einem erfahrenen Autorenteam die OP-Praxis der Plastischen …
Phosphoinositide 3-kinase in Health and Disease
From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of …
Retroviruses
Among the first diseases for which a viral etiology was esta- blished were tumors, lymphomas, and sarcomas in chickens, shown by Ellermann and Bang (1908) and Rous (1910) to be …
Thoraxtumoren
Das Bronchialkarzinom zählt zu den am häufigsten in den Industrieländern vorkommenden Tumoren und hat deshalb eine große klinische und soziale Bedeutung. Im Mittelpunkt des …