This volume of articles (most published, some new) is a follow-up to the late Wesley C. Salmons widely read collection Causality And Explanation (OUP 1998). It contains both published and unpublished articles, and focuses on two related areas of inquiry: First, is science a rational enterprise? Secondly, does science yield objective information about our world, even the aspects that we cannot observe directly? Salmons own take is that objective knowledge of the world is possible, and his work in these articles centers around proving that this can be so. Salmons influential standing in the field ensures that this volume will be of interest to both undergraduates and professional philosophers, primarily in the philosophy of science.