Protein kinases play a critical role in cellular processes thatimpact overall organismal health and function. Of the kinases thatcollectively make up the Human Kinome, CK2 has garnered specialattention because of its significant role in the generation of thehuman phosphoproteome. The role CK2 plays in the development ofcancer and other disease has also made it of significant interestfor its potential role in future therapeutics. Protein KinaseCK2 comprehensively brings together the varied work being doneon this critical enzyme.
Protein Kinase CK2 is logically divided into threesections. The first section reviews key molecular and structuralaspects of the enzyme. The second section looks at functionalaspects of CK2 and the diverse roles it plays in cellulardevelopment, function, and health. The final section focuses on CK2and cancer, looking at the impacts of the kinase on neoplasticdevelopment and its rapidly developing role as a therapeuticagent.
With contributions from the world's leading experts in thefield, Protein Kinase CK2 will serve as an invaluable guideto the expanding and vibrant body of research being performed onthis enzyme. This will be an essential volume for anyone working inthe fields of biochemistry, protein science, signal transduction, metabolic regulation, and cancer biology and therapeutics.
Lorenzo A. Pinna is Professor in the Department ofBiomedical Sciences at the University of Padua, Padua, Italy.
Also Published in the Wiley-IUBMB Series on Biochemistry andMolecular Biology:
Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology
Edited by Cesar G. Fraga