Dwight B. Wilmerding is only twenty-eight, but he's having a midlife crisis. He lives a dissolute existence in a tiny apartment with three (sometimes four) slacker roommates, holds a mind-numbing job at the pharmaceutical giant Pfizer, and has a chronic inability to make up his mind. Encouraged by one of his roommates to try an experimental drug meant to banish indecision, Dwight jumps at the chance (not without some vacillation about the hazards of jumping) and swallows the first fateful pill. And when all at once he is "pfired" by Pfizer and invited to a rendezvous in exotic Ecuador with the girl of his long-ago prep-school dreams, he finds himself on the brink of a new life. The trouble-well, one of the troubles-is that Dwight can't decide if the pills are working. Deep in the jungles of the Amazon, in the foreign country of a changed outlook, his would-be romantic escape becomes a hilarious journey into unbidden responsibility and unwelcome knowledge-and an unexpected raison d'etre.