An essential outline of the main facets of polypharmacology indrug discovery research
Extending drug discovery opportunities beyond the "one drug, onetarget" philosophy, a polypharmacological approach to the treatmentof complex diseases is emerging as a hot topic in both industry andacademic research. Polypharmacology in Drug Discovery presents anoverview of the various facets of polypharmacology and how it canbe applied as an innovative concept for developing medicines fortreating bacterial infections, epilepsy, cancer, psychiatricdisorders, and more. Filled with a collection of instructive casestudies that reinforce the material and illuminate the subject, this practical guide:
Covers the two-sided nature of polypharmacology--itscontribution to adverse drug reactions and its benefit in certaintherapeutic drug classes
Addresses the important topic of polypharmacology in drugdiscovery, a subject that has not been thoroughly covered outsideof scattered journal articles
Overviews state-of-the-art approaches and developments to helpreaders understand concepts and issues related topolypharmacology
Fosters interdisciplinary drug discovery research by embracingcomputational, synthetic, in vitro and in vivo pharmacological andclinical aspects of polypharmacology
A clear road map for helping readers successfully navigatearound the problems involved with promiscuous ligands and targets, Polypharmacology in Drug Discovery provides real examples, in-depthexplanations and discussions, and detailed reviews and opinions tospark inspiration for new drug discovery projects.