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Gastrointestinal Regulatory Peptides
Since the discovery of the pancreatic secretagogue secretin by W. M. BAYLISS and E. H. STARLING at the inception of the twentieth century, intense interest has focused on numerous, …
Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity
Advances in molecular biology describing important enzyme systems involved in drug conjugation and deconjugation reactions and recent work indicating the importance of drug and …
Pharmacology of Smooth Muscle
Eighty years have passed since Arthur Heffter, the founder of this handbook series, invited in 1913 eminent scientists from different parts of the world to contribute. At that time …
The Pharmacology of Monoclonal Antibodies
It has been almost 20 years since the discovery by Kohler and Milstein of the technology to produce monoclonal antibodies (MAbs), a discovery that promised revolutionary changes in …
Chemotherapy of Viral Infections
" . . . the motto for the therapeutics of the future will have to be de sedibus et causis pharmacorum. " P. EHRLICH, 1909 Exciting events in the basic disciplines of virology, …
Heme and Hemoproteins
The study of the biological effects of foreign chemicals (whether therapeutic drugs or chemicals present at work or in the environment) interests the biologist from a number of …
Physiology and Pharmacology of the Blood-Brain Barrier
The blood-brain barrier is still not completely understood and therefore the subject of fascinating study. How are endogenous substances transported through the blood-brain …
Hypolipidemic Agents
The major cause of death in the Western world is some form of vascular disease; and principal among these forms is atherosclerotic heart disease (ASHD). Although much is known …
Pharmacology of Asthma
This volume forms part of a prestigious series and covers the latest advances in our understanding of the pathophysiology and treatment of asthma. Our understanding of asthma has …
GTPases in Biology II
Recent advances in molecular biology have shown GTPases and phosphoproteins to be the paramount molecular switches uti- lized intracellularly in biological systems. The origins of …