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Methadone Treatment for Opioid Use Disorder
Methadone is a Food and Drug Administration- (FDA-) approved medication for treating opioid use disorder (OUD), a chronic brain disease that affects more than 2.7 million people in …
Neuroforensics
Technological advances in noninvasive neuroimaging, neurophysiology, genome sequencing, and other methods together with rapid progress in computational and statistical methods and …
Sex Differences in Brain Disorders
Accumulating evidence gathered over the past three decades has demonstrated a biological basis for differences between men and women with respect to clinical features and treatment …
Exploring Psychedelics and Entactogens as Treatments for Psychiatric Disorders
Psychiatric illnesses - such as major depressive disorder, anxiety disorder, substance use disorder, and posttraumatic stress disorder (PTSD) - are widely prevalent and represent a …
Neuroscience Trials of the Future
On March 3-4, 2016, the National Academies of Sciences, Engineering, and Medicines Forum on Neuroscience and Nervous System Disorders held a workshop in Washington, DC, bringing …
Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships
Chronic pain is one of the most prevalent, costly, and disabling health conditions in the United States. Estimates show that more than 11 percent of the American population suffer …
Assessing the Impact of Applications of Digital Health Records on Alzheimer's Disease Research
Health information technology is providing patients, clinicians, and researchers with access to data that will enable novel approaches to science and medicine. Digital health …
Transgenic Neuroscience Research
To examine the promise, concerns, and challenges related to neuroscience research using genetically modified nonhuman primates, the National Academies of Sciences, Engineering, and …
Biomarkers of Neuroinflammation
Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is …
Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships
Chronic pain is one of the most prevalent, costly, and disabling health conditions in the United States. Estimates show that more than 11 percent of the American population suffer …
From Molecular Insights to Patient Stratification for Neurological and Psychiatric Disorders
While significant progress has been seen in fields such as cardiovascular medicine and cancer in improving patient stratification and developing targeted drugs based on genetic …
Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders
Compared with other disease areas, central nervous system (CNS) disorders have had the highest failure rate for new compounds in advanced clinical trials. Most CNS drugs fail …