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Percept, Decision, Action
Seemingly simple behaviours turn out, on reflection, to be discouragingly complex. For many years, cognitive operations such as sensation, perception, comparing percepts to stored …
Cortical Development
To understand the brain and its devastating diseases, we need to reveal the mechanisms that produce it and the ways in which it can constantly change throughout a lifetime. This …
Osteoarthritic Joint Pain
Osteoarthritis is a chronic degenerative disease associated with joint pain and loss of joint function. It has an estimated incidence of four in every 100 people and significantly …
Empathy and Fairness
Empathy is the process that allows us to share the feelings and emotions of others, in the absence of any direct emotional stimulation to the self. Humans can feel empathy for …
Understanding Nicotine and Tobacco Addiction
Cigarette smoking is estimated to lead to 4.9 million premature deaths per year worldwide. This is predicted to rise to 10 million by 2020. In western countries it kills half of …
Mechanisms and Biological Significance of Pulsatile Hormone Secretion
Many endocrine systems use the intermittent or pulsatile release of hormones to transmit complex information into cellular compartments of the body. Although the actual …
The Molecular Basis of Skeletogenesis
This book brings together a cross-fertilization of ideas between human molecular genetics, developmental biology, tissue biology and the biochemistry of cell signalling pathways, …
Genetics of Autoimmunity
This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the …
The Genetics and Biology of Sex Determination
Although nature employs a wide variety of sex-determining mechanisms, it is only comparatively recently that the tools have become available for these to be explored at the …
Drug Resistance in Epilepsy
Drug resistance in epilepsy is an important clinical problem. About 20% of patients diagnosed as having epilepsy fail to respond to prescribed antiepileptic drugs and continue to …
Pathological Pain
Recent decades have seen an explosion of research into the mechanisms of pain in both normal and pathological states. Neurobiological studies have revealed the detailed …
Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is the most common respiratory disorder of adults in the developed world and is the fourth main cause of death in the USA. It is also …