Located off a desolate stretch of Interstate 50, Desperation, Nevada, has few connections with the rest of the world. It is a place, though, where the seams between worlds are thin. And it is a place where several travelers are abducted by Collie Entragian, the maniacal police officer of Desperation. Entragian uses various ploys for the abductions, from an arrest for drug possession to "rescuing" a family from a nonexistent gunman. There's something very wrong here, all right, and Entragian is only the surface of it.
The secrets embedded in Desperation's landscape, and the evil that infects the town like some viral hot zone, are both awesome and terrifying. But as one of the travelers, young David Carver, seems to know--though it scares him nearly to death to realize it--so are the forces summoned to combat them.